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Title: Possible pathway for ifosfamide degradation via Fe-TiO2 assisted photo catalysis
Authors: Constantin, Lucian Alexandru 
Constantin, Mirela Alina 
Nitoi, Ines 
Chiriac, Florentina Laura 
Pascu, Luoana Florentina 
Galaon, Toma 
Keywords: Fe doped TiO2;Ifosfamide;Heterogeneous photo catalysis;Degradation intermediates
Issue Date: 2018
Publisher: SYSCOM 18 SRL
Ifosfamide (IF) degradation from aqueous system via UV-Vis Fe-TiO2 system was studied for a photo
catalyst dose of 200 mg/L and an irradiation time up to 240 min. IF degradation efficiency was monitored via
Liquid Chromatography-Mass Spectrometry technique (LC-MS). Experimental photocatalytic tests were
performed both in the absence and presence of 2-propanol and F- radicals’ scavengers and the results
proved that IF degradation occurs most likely in the bulk solution. Experimental results showed that
degradation efficiencies for IF varied between 39.52% in the presence of 2-propanol and 70.70% in the
scavengers’ absence. Six degradation intermediates were identified using the same LC-MS technique and
a three stage degradation pathway was proposed based on both available literature data and evolution of
degradation intermediates peaks.
Revista de Chimie (Bucharest), vol. 69, no. 11, pag. 4134-4137, 2018
ISSN: 0034-7752
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