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Title: Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) – Synthesis, Spectral Characterization and Biological Activity
Authors: Calinescu, Mirela 
Oprea, Ovidiu 
Stoica, Catalina 
Nita-Lazar, Mihai 
Mihalache, Madalina 
Keywords: Biguanides;Usnic acid;Coordination compounds;Biological activity
Issue Date: Apr-2020
Publisher: SYSCOM 18 SRL
Four coordination compounds of Pd(II), Pt(II) and Pt(IV) with usnic acid (H3AU) and 1-(o-tolyl)biguanide (TB) as ligands have been synthesized in view of their potential as antimicrobial, antifungal and antitumor agents. The metal complexes have been characterized by elemental and thermogravimetrical analyses, infrared and electronic spectra. Based on these studies, the following formulas have been proposed for the complexes: [Pd(TB)(H3AU)]PdCl4 (C1), [Pd(TB)(H2AU)] CH3COO (C2), [Pt(TB)(H2AU)Cl2]Cl (C3) and [Pt(TB)(H2AU)]Cl (C4), where H2AU is deprotonated usnic acid. The in vitro biological activities of the new complexes were tested against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 10231 and HeLa tumor cells. All complexes were found to have good biological properties and therefore they can be further explored in therapeutic applications.
Revista de Chimie, 71 (4), 2020, pp. 336-346
ISSN: 2668-8212
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