Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1887
DC Field | Value | Language |
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dc.contributor.author | Gheorghe Barbu, Irina | en_US |
dc.contributor.author | Czobor Barbu, Ilda | en_US |
dc.contributor.author | Popa, Laura Ioana | en_US |
dc.contributor.author | Gradisteanu-Pircalabioru, Gratiela | en_US |
dc.contributor.author | Popa, Marcela | en_US |
dc.contributor.author | Marutescu, Luminita | en_US |
dc.contributor.author | Nita-Lazar, Mihai | en_US |
dc.contributor.author | Banciu, Alina | en_US |
dc.contributor.author | Stoica, Catalina | en_US |
dc.contributor.author | Gheorghe, Stefania | en_US |
dc.contributor.author | Lucaciu, Irina | en_US |
dc.contributor.author | Sandulescu, Oana | en_US |
dc.contributor.author | Paraschiv, Simona | en_US |
dc.contributor.author | Surleac, Marius | en_US |
dc.contributor.author | Talapan, Daniela | en_US |
dc.contributor.author | Muntean, Andrei Alexandru | en_US |
dc.contributor.author | Preda, Madalina | en_US |
dc.contributor.author | Muntean, Madalina Maria | en_US |
dc.contributor.author | Dragomirescu, Cristina Cerasela | en_US |
dc.contributor.author | Popa, Mircea Ioan | en_US |
dc.contributor.author | Chifiriuc, Mariana Carmen | en_US |
dc.date.accessioned | 2022-09-15T15:15:19Z | - |
dc.date.available | 2022-09-15T15:15:19Z | - |
dc.date.issued | 2022-09-14 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/1887 | - |
dc.description | Antimicrobial Resistance & Infection Control, (2022), vol. 11:115, https://doi.org/10.1186/s13756‑022‑01156‑1 | en_US |
dc.description.abstract | Both clinical and aquatic isolates exhibited high MDR rates, especially the Ab strains isolated from nosocomial infections and hospital effluents. The phenotypic resistance profiles and MDR rates have largely varied by sampling point and geographic location. The highest MDR rates in the aquatic isolates were recorded in Galați WWTP, followed by Bucharest. The Ab strains harbored mostly blaOXA‑23, blaOXA‑24, blaSHV, blaTEM and blaGES, while Pa strains blaIMP, blaVIM, blaNDM, blaVEB, blaGES and blaTEM, with high variations depending on the geographical zone and the sampling point. The WGS analysis revealed the presence of antibiotic resistance genes (ARGs) to other antibiotic classes, such as aminoglycosides, tetracyclines, sulphonamides, fosfomycin, phenicols, trimethoprim‑sulfamethoxazole as well as class 1 integrons. The molecular analyses highlighted: (i) The presence of epidemic clones such as ST2 for Ab and ST233 and ST357 for Pa; (ii) The relatedness between clinical and hospital wastewater strains and (iii) The possible dissemination of clinical Ab belonging to ST2 (also proved in the conjugation assays for blaOXA‑23 or blaOXA‑72 genes), ST79 and ST492 and of Pa strains belonging to ST357, ST640 and ST621 in the wastewaters. Our study reveals the presence of CP‑producing Ab and Pa in all sampling points and the clonal dissemination of clinical Ab ST2 strains in the wastewaters. The prevalent clones were correlated with the presence of class 1 integrons, suggesting that these isolates could be a significant reservoir of ARGs, being able to persist in the environment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.subject | Antimicrobial resistance | en_US |
dc.subject | Nonfermenting gram‑negative Bacilli | en_US |
dc.subject | Nosocomial infections | en_US |
dc.subject | Wastewater | en_US |
dc.subject | Epidemic clones | en_US |
dc.title | Temporo‑spatial variations in resistance determinants and clonality of Acinetobacter baumannii and Pseudomonas aeruginosa strains from Romanian hospitals and wastewaters | en_US |
dc.type | research article | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
dc.contributor.affiliation | National Research and Development Institute for Industrial Ecology, ECOIND | en_US |
dc.contributor.affiliation | National Research and Development Institute for Industrial Ecology, ECOIND | en_US |
dc.contributor.affiliation | National Research and Development Institute for Industrial Ecology, ECOIND | en_US |
dc.contributor.affiliation | National Research and Development Institute for Industrial Ecology, ECOIND | en_US |
dc.contributor.affiliation | National Research and Development Institute for Industrial Ecology, ECOIND | en_US |
dc.contributor.affiliation | National Institute for Infectious Diseases “Matei Bals”, Bucharest | en_US |
dc.contributor.affiliation | National Institute for Infectious Diseases “Matei Bals”, Bucharest | en_US |
dc.contributor.affiliation | National Institute for Infectious Diseases “Matei Bals”, Bucharest | en_US |
dc.contributor.affiliation | National Institute for Infectious Diseases “Matei Bals”, Bucharest | en_US |
dc.contributor.affiliation | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | en_US |
dc.contributor.affiliation | University of Medicine and Pharmacy “Carol Davila”, Bucharest | en_US |
dc.contributor.affiliation | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | en_US |
dc.contributor.affiliation | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | en_US |
dc.contributor.affiliation | University of Medicine and Pharmacy “Carol Davila”, Bucharest | en_US |
dc.contributor.affiliation | University of Bucharest, Romania | en_US |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | research article | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.dept | National Research and Development Institute for Industrial Ecology, ECOIND | - |
crisitem.author.dept | National Research and Development Institute for Industrial Ecology, ECOIND | - |
crisitem.author.dept | National Research and Development Institute for Industrial Ecology, ECOIND | - |
crisitem.author.dept | National Research and Development Institute for Industrial Ecology, ECOIND | - |
crisitem.author.dept | National Institute for Infectious Diseases “Matei Bals”, Bucharest | - |
crisitem.author.dept | National Institute for Infectious Diseases “Matei Bals”, Bucharest | - |
crisitem.author.dept | National Institute for Infectious Diseases “Matei Bals”, Bucharest | - |
crisitem.author.dept | National Institute for Infectious Diseases “Matei Bals”, Bucharest | - |
crisitem.author.dept | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | - |
crisitem.author.dept | University of Medicine and Pharmacy “Carol Davila”, Bucharest | - |
crisitem.author.dept | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | - |
crisitem.author.dept | “Cantacuzino” National Medical‑Military Research and Development Institute, Bucharest | - |
crisitem.author.dept | University of Medicine and Pharmacy “Carol Davila”, Bucharest | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.orcid | 0000-0002-5099-1311 | - |
crisitem.author.orcid | 0000-0002-2347-508X | - |
crisitem.author.orcid | 0000-0003-1352-157X | - |
crisitem.author.orcid | 0000-0002-3582-7695 | - |
crisitem.author.orcid | 0000-0001-6413-3003 | - |
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Zona Rosie Antimicrobial Resistance.pdf | Research Article | 3.18 MB | Adobe PDF | View/Open |
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