Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/791
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Galaon, Toma | - |
dc.contributor.author | David, Victor | - |
dc.date.accessioned | 2017-04-06T08:27:55Z | - |
dc.date.available | 2017-04-06T08:27:55Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1615-9314 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/791 | - |
dc.description | Journal of Separation Science Volume 34 | en_US |
dc.description.abstract | The most encountered situations in reversed-phase liquid chromatography for temperature dependence of retention are those obeying the linear equation known as the van’t Hoff plot. When studying compounds that are involved in structural modifications, it is likely that the temperature dependences of their retention factors do not follow this rule. It is the aim of this paper to report some particular cases when compounds involved in tautomeric interconversion have a different retention behavior with temperature: a deviation from the linearity of ln k on 1/T, or, in certain temperature ranges, temperature increase leading to a retention increase. Examples of compounds exhibiting deviation from the van’t Hoff temperature dependence are piroxicam, drotaverine, vincamine, and epivincamine. A simple thermodynamic model relying on tautomeric equilibria in mobile phase is proposed for these compounds, which gives a polynomial dependence between ln k and 1/T. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-VCH Verlag GmbH & Co | en_US |
dc.subject | Drotaverine | en_US |
dc.subject | Piroxicam | en_US |
dc.subject | Reversed-phase LC | en_US |
dc.subject | Tautomerism | en_US |
dc.subject | Thermodynamics | en_US |
dc.subject | Van’t Hoff plot | en_US |
dc.subject | Vincamine | en_US |
dc.title | Deviation from van’t Hoff dependence in RPLC induced by tautomeric interconversion observed for four compounds | en_US |
dc.type | Article | en_US |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | reserved | - |
item.openairetype | Article | - |
crisitem.author.dept | National Research and Development Institute for Industrial Ecology, ECOIND | - |
crisitem.author.dept | University of Bucharest, Romania | - |
crisitem.author.orcid | 0000-0001-8621-922X | - |
Appears in Collections: | Articles |
Files in This Item:
File | Description | Size | Format | Existing users please |
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A ISI JSS TOMI ANTIVH 2014.pdf | 245.93 kB | Adobe PDF | Request a copy |
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