Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/791
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dc.contributor.authorGalaon, Toma-
dc.contributor.authorDavid, Victor-
dc.date.accessioned2017-04-06T08:27:55Z-
dc.date.available2017-04-06T08:27:55Z-
dc.date.issued2011-
dc.identifier.issn1615-9314-
dc.identifier.urihttp://hdl.handle.net/123456789/791-
dc.descriptionJournal of Separation Science Volume 34en_US
dc.description.abstractThe most encountered situations in reversed-phase liquid chromatography for temperature dependence of retention are those obeying the linear equation known as the van’t Hoff plot. When studying compounds that are involved in structural modifications, it is likely that the temperature dependences of their retention factors do not follow this rule. It is the aim of this paper to report some particular cases when compounds involved in tautomeric interconversion have a different retention behavior with temperature: a deviation from the linearity of ln k on 1/T, or, in certain temperature ranges, temperature increase leading to a retention increase. Examples of compounds exhibiting deviation from the van’t Hoff temperature dependence are piroxicam, drotaverine, vincamine, and epivincamine. A simple thermodynamic model relying on tautomeric equilibria in mobile phase is proposed for these compounds, which gives a polynomial dependence between ln k and 1/T.en_US
dc.language.isoen_USen_US
dc.publisherWILEY-VCH Verlag GmbH & Coen_US
dc.subjectDrotaverineen_US
dc.subjectPiroxicamen_US
dc.subjectReversed-phase LCen_US
dc.subjectTautomerismen_US
dc.subjectThermodynamicsen_US
dc.subjectVan’t Hoff ploten_US
dc.subjectVincamineen_US
dc.titleDeviation from van’t Hoff dependence in RPLC induced by tautomeric interconversion observed for four compoundsen_US
dc.typeArticleen_US
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextreserved-
item.openairetypeArticle-
crisitem.author.deptNational Research and Development Institute for Industrial Ecology, ECOIND-
crisitem.author.deptUniversity of Bucharest, Romania-
crisitem.author.orcid0000-0001-8621-922X-
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