Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/808
Title: Ecotoxicological effect of pharmaceutical chemicals on aquatic organism
Authors: Gheorghe, Stefania 
Lucaciu, Irina 
Iancu, Vasile 
Petre, Jana 
Grumaz, Rozalia 
Issue Date: 2010
Abstract: 
The scientifically researches have show that the pharmaceutical ingredients are frequently present in the environment aquatic component (surface water). This result has conducted at a regulatory mobility and scientific concerns for potentially environment impact assessment of active biologically pharmaceutical compounds. Within this context and according with REACH Regulation, the present work assessed the aquatic acute toxicity (LC50 / EC50) for the most abundantly used pharmaceuticals from the class of analgesics (ibuprophen, diclophenac, acetaminophen, naproxen, ketoprophen and indometacin), carbamazepine and caffeine. The acute toxicity biotests were conducted on fresh water fish (Cyprinus carpio sp. – a common species from Romanian surface waters), crustacean (Daphnia magna sp.) and luminescent bacteria (Vibrio ficheri sp.). To comply the OECD/ISO methodology, the testing procedure have followed the biological parameters: mortality, behavior and physiological modifications (for fish); immobilization and reproduction inhibition (for crustacean); inhibition and stimulation (for luminescent bacteria). Analytical control of test solutions concentrations was performed through HPLC-UV method – ECOIND metodology.
Description: 
INTERNATIONAL WORKSHOP “GLOBAL and REGIONAL ENVIRONMENTAL PROTECTION”
- GLOREP 2010 –
URI: http://hdl.handle.net/123456789/808
Appears in Collections:Conference Papers

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