Ecotoxicological effect of pharmaceutical chemicals on aquatic organism

Abstract

The scientifically researches have show that the pharmaceutical ingredients are frequently present in the environment aquatic component (surface water). This result has conducted at a regulatory mobility and scientific concerns for potentially environment impact assessment of active biologically pharmaceutical compounds. Within this context and according with REACH Regulation, the present work assessed the aquatic acute toxicity (LC50 / EC50) for the most abundantly used pharmaceuticals from the class of analgesics (ibuprophen, diclophenac, acetaminophen, naproxen, ketoprophen and indometacin), carbamazepine and caffeine. The acute toxicity biotests were conducted on fresh water fish (Cyprinus carpio sp. – a common species from Romanian surface waters), crustacean (Daphnia magna sp.) and luminescent bacteria (Vibrio ficheri sp.). To comply the OECD/ISO methodology, the testing procedure have followed the biological parameters: mortality, behavior and physiological modifications (for fish); immobilization and reproduction inhibition (for crustacean); inhibition and stimulation (for luminescent bacteria). Analytical control of test solutions concentrations was performed through HPLC-UV method – ECOIND metodology.