Dumitru, RalucaRalucaDumitruNegrea, Sorina ClaudiaSorina ClaudiaNegreaPacurariu, CorneliaCorneliaPacurariuSurdu, AdrianAdrianSurduIanculescu, AdelinaAdelinaIanculescuPop, AnielaAnielaPopManea, FloricaFloricaManea2022-02-092022-02-092021-03http://hdl.handle.net/123456789/1789Nanomaterials, 2021, 11, 740, https://doi.org/10.3390/nano11030740.CuBi2O4 synthesized by thermolysis of a new Bi(III)-Cu(II) oxalate coordination compound, namely Bi2Cu(C2O4)4 ·0.25H2O, was tested through its integration within carbon nanofiber paste electrode, namely CuBi/carbon nanofiber (CNF), for the electrochemical detection of amoxicillin (AMX) in the aqueous solution. Thermal analysis and IR spectroscopy were used to characterize a CuBi2O4 precursor to optimize the synthesis conditions. The copper bismuth oxide obtained after a heating treatment of the precursor at 700 ◦C/1 h was investigated by X-ray diffraction and scanning electron microscopy. The electrochemical behavior of CuBi/CNF in comparison with the CNF paste electrode showed the electrocatalytic activity of CuBi2O4 toward amoxicillin detection. Two potential detections, with one at the potential value of +0.540 V/saturated calomel electrode (SCE) and the other at the potential value of −1.000 V/SCE, were identified by cyclic voltammetry, which was exploited to develop the enhanced voltammetric and/or amperometric detection protocols. Better electroanalytical performance for AMX detection was achieved for CuBi/CNF using differentialpulsed and square-wave voltammetries than others reported in the literature. Very nice results obtained through anodic and cathodic currents recorded at +0.750 V/SCE and −1.000 V/SCE in the same time period using a pseudo-multiple-pulsed amperometry technique showed the great potential of the CuBi/CNF paste electrode for practical applications in amoxicillin detection in aqueous solutions.enCuBi2O4 electrocatalystAmoxicillinElectrochemical detectionCuBi2O4-carbon nanofiber paste electroderesearch article10.3390/nano11030740