Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/784
DC Field | Value | Language |
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dc.contributor.author | Galaon, Toma | - |
dc.contributor.author | Vacaresteanu, Catalina | - |
dc.contributor.author | Anghel, Dan-Florin | - |
dc.contributor.author | David, Victor | - |
dc.date.accessioned | 2017-04-06T07:33:42Z | - |
dc.date.available | 2017-04-06T07:33:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1942-7611 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/784 | - |
dc.description | Drug Testing and Analysis Volume 6 | en_US |
dc.description.abstract | Nine important 1,4-benzodiazepines and zolpidem were characterized by liquid chromatography-mass spectrometry using a multimode ionization source able to generate ions using both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), and a single quadrupole mass analyzer. An optimum chromatographic separation was applied for all target compounds in less than 8 minutes using a Zorbax Eclipse Plus column (100 x 4.6 mm, 3.5 μm) kept at 35°C and a 0.3% HCOOH/ ACN/IPA (61:34:5) mobile phase pumped at 1 ml/min. Optimization of LC-MS method generated low limit of quantitation (LOQ) values situated in the range 0.3–20.5 ng/ml. Comparison between differences in method sensitivity, under specified chromatographic conditions, when using ESI-only, APCI-only, and simultaneous ESI-APCI ionization with such a multimode source was discussed. Mixed ESI-APCI(+) mode proved to be the most sensitive ionization generating an average 35% detector response increase compared to ESI-only ionization and 350% detector response increase with respect to APCI-only ionization. Characterization of the nine benzodiazepines and zolpidem concerning their MS fragmentation pathway following ‘in-source’ collision-induced dissociation is discussed in detail and some general trends regarding these fragmentations are set. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | John Wiley & Sons, Ltd | en_US |
dc.subject | Benzodiazepines | en_US |
dc.subject | LC-MS | en_US |
dc.subject | Fragmentation pathway | en_US |
dc.subject | In-source CID | en_US |
dc.subject | Simultaneous dual ESI-APCI ionization | en_US |
dc.title | Simultaneous ESI-APCI(+) ionization and fragmentation pathways for nine benzodiazepines and zolpidem using single quadrupole LC-MS | en_US |
dc.type | Article | en_US |
item.languageiso639-1 | en_US | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | reserved | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Articles |
Files in This Item:
File | Description | Size | Format | Existing users please |
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A ISI DTA TOMI BENZO 2014.pdf | 783.68 kB | Adobe PDF | Request a copy |
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