The lipophilicity of some hazardous substances estimated by high performance liquid chromatography and computed by various methods

The lipophilicity of some hazardous substances (emerging pesticides and some PAHs) was investigated by high performance liquid chromatography, on four chromatographic columns of RP-18, RP-8, phenyl and CN, with two types of mobile phases based on acetonitrile and methanol. The investigated lipophilicity indices were both experimentally (log kw, S and u0) and theoretically expressed. In order to find an objective manner of quantitative comparison of different chemically bonded stationary phases and evaluate the reliability of the obtained results some comparison procedures based on correlation diagrams and matrices were performed. The results indicated that all the stationary phases were useful for the lipophilicity investigation and that the experimentally and theoretically lipophilicity indices were highly correlated. Moreover, it was suggested that methanol used as an organic modifier led to more significant lipophilicity indices.