Possible pathway for ifosfamide degradation via Fe-TiO2 assisted photo catalysis

Ifosfamide (IF) degradation from aqueous system via UV-Vis Fe-TiO2 system was studied for a photo
catalyst dose of 200 mg/L and an irradiation time up to 240 min. IF degradation efficiency was monitored via
Liquid Chromatography-Mass Spectrometry technique (LC-MS). Experimental photocatalytic tests were
performed both in the absence and presence of 2-propanol and F- radicals’ scavengers and the results
proved that IF degradation occurs most likely in the bulk solution. Experimental results showed that
degradation efficiencies for IF varied between 39.52% in the presence of 2-propanol and 70.70% in the
scavengers’ absence. Six degradation intermediates were identified using the same LC-MS technique and
a three stage degradation pathway was proposed based on both available literature data and evolution of
degradation intermediates peaks.