Assessment of adverse effects of some pharmaceuticals products on aquatic organisms and ecological risk characterization, in accordance with international regulations

The project proposed the assessment of adverse effects of some pharmaceuticals products on aquatic organisms and ecological risk characterization, in accordance with international regulations in force. In this regard, based on the existing information of the scientific literature and laboratory experiments that aim, in particular, aquatic bioassays of acute and chronic toxicity on fish, algae, crustaceans and bacteria were established the ecotoxicological criteria. Moreover, the environmental risk induced by the active substances was quantified. The acute toxicity bioassays led to the acute lethal concentration establishment (LC50 - if bioassays were conducted on fish), acute mean inhibitory concentration (CE50- if bioassays were conducted on bacteria) and immobilization (CE50 - if bioassays were performed on crustaceans and algae). Also, chronic toxicity bioassay led to the maximum permissible concentration setting in water - MATC (fish and shellfish) and chronic no observed effect concentration values - NOEC.